Le Thu, 22 May 2025 06:00:00 -0400

Longitudinal research in autism has contributed a wealth of knowledge about etiological factors, development from childhood through adulthood, life course changes and needs, as well as longer-term adult outcomes for individuals on the spectrum and their family members. This research is essential to better understand the needs of individuals as they age. However, along with the as yet unrealized opportunities to understand an individual in more nuanced ways across time, there are challenges to...

Le Thu, 22 May 2025 06:00:00 -0400

Autism diagnosis before age three to expedite access to critical services is a public health priority in the United States. Still, the average age of autism diagnosis is 49 months with substantial variability across states. By examining policy-defined as laws, regulations, procedures, administrative actions, incentives, or voluntary practices of governments or other institutions-modifiable structural drivers of early (or late) autism diagnosis may be identified. We, therefore, sought to identify...

Le Thu, 22 May 2025 06:00:00 -0400

CONCLUSIONS: Before the adoption of DSM-5 diagnostic criteria for ASD, ICD-10 diagnoses related to autism were relatively stable in the long run, with an 8-year follow-up. The next step is to assess the longitudinal diagnostic stability of ASD after the adoption of DSM-5 criteria.

Le Thu, 22 May 2025 06:00:00 -0400

This study explored the causal relationships between gut microbiota, blood metabolites and autism spectrum disorder (ASD) in children and assessed whether metabolites mediate the relationship between microbiota and ASD. Using Mendelian randomization (MR), causal links between gut microbiota, blood metabolites and ASD were analysed, alongside reverse MR to examine reverse causality. A two-step MR mediation analysis was used to assess metabolite mediation. The study identified 15 gut microbiota...

Le Thu, 22 May 2025 06:00:00 -0400

INTRODUCTION: Insomnia is common in children and adolescents with autism spectrum disorder (ASD) and/or attention deficit and hyperactivity disorder (ADHD), with significant implications for quality of life and prognosis. Although non-pharmacological interventions represent the first-line approach, they are not always effective. Therefore, it is important to determine when a pharmacological treatment can be indicated and which compound to prefer based on evidence of efficacy and safety.

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSIONS: Incorporating PGx testing into the medical workup did not improve outcomes, with all treatment groups achieving similar levels of polypharmacy and quality of life. Analysis of secondary outcomes revealed some differences in medication prescribing when stratifying by congruency; however, no differences were observed between treatment groups for all other secondary outcomes.

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSIONS: This study highlights the distinct behavioral profiles in ASD and ID only using CBCL. Introducing this inventory as a comprehensive scale for understanding developmental disorders. Yet, our findings call for more accurate assessment and intervention strategies for each condition.

Le Wed, 21 May 2025 06:00:00 -0400

Current evidence suggests the possibility that autistic people may be at more risk of COVID-19 infection, hospitalisation, and mortality than the general population. Previous studies, however, are either limited in scale or do not investigate potential risk factors. Research into risk factors focused on general population samples. The current study aims to investigate these risk factors in the autistic population. Using data-linkage and a whole-country population, this study modelled...

Le Wed, 21 May 2025 06:00:00 -0400

The atypical sensory features and high comorbidity of anxiety disorders in individuals with autism spectrum disorder (ASD) are attracting increasing attention. Among individuals with ASD, those who exhibit heightened sensory hyperresponsiveness tend to show enhanced temporal processing of sensory stimuli, despite no observed differences in stimulus detection thresholds. A previous study reported the role of anxiety in modulating emotion-cued changes of visual temporal resolution in ASD. Building...

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSIONS: Despite the age being 18 years and older (i.e., not exclusively elderly), most fractures were considered to be low-energy and occurred in the extremities, but this varied by subgroup. This study identified the activities that led to a fracture event, which may inform fracture prevention efforts such as adjunct therapies.

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSIONS: The findings suggest that alterations in complement system proteins, particularly reduced serum C1q levels, may be associated with ASD. Given C1q's critical role in synaptic pruning and neuroimmune regulation, these results support the hypothesis that complement system dysfunction may contribute to the pathophysiology of ASD.

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSION: Findings suggest significant somatic symptoms and health anxiety in autistic adults that warrants clinical attention.

Le Wed, 21 May 2025 06:00:00 -0400

Vee is a nonbinary (sex assigned at birth: female) 16-year-old 11th grader presenting for their initial multidisciplinary team assessment (including developmental-behavioral pediatrics and psychological assessment). Vee's family first became concerned about their development when they were in pre-kindergarten. The school had concerns related to autism and provided Vee with an Individualized Education Plan (IEP) for autism-related services, although a formal medical diagnosis was never made. Vee...

Le Wed, 21 May 2025 06:00:00 -0400

CONCLUSIONS: The AUT-MENU study is expected to yield significant insights and improvements in meal acceptance among individuals with ASD, particularly through the introduction of targeted menus in collective catering settings both in care centers and schools.

Le Wed, 21 May 2025 06:00:00 -0400

No abstract