Le Mon, 09 Feb 2026 06:00:00 -0500

No abstract

Le Mon, 09 Feb 2026 06:00:00 -0500

Interleukin-17 (IL-17) is a pleiotropic cytokine produced mainly by peripheral T helper 17 cells. Yet, the brain functions of IL-17 derived from central nervous cells remain poorly understood. Here, we find an aberrant IL-17A signaling in the cerebellum of Fmr1-KO mice, a well-established genetic model for autism spectrum disorder (ASD). Cerebellar IL-17A, derived exclusively from microglia, is essential for the regulation of social behaviors by maintaining neuronal excitability and selectively...

Le Mon, 09 Feb 2026 06:00:00 -0500

Post-diagnostic support is a critical yet underdeveloped aspect of dementia care, especially for autistic adults who present with distinct cognitive, sensory, and communication needs. Although interventions such as medication management, psychosocial support, environmental modifications, and carer training are known to improve outcomes, their relevance and accessibility for autistic individuals remain poorly understood. As part of the Second International Summit on Intellectual Disability and...

Le Mon, 09 Feb 2026 06:00:00 -0500

ObjectiveAutism spectrum disorder (ASD) can affect vision both directly through central nervous system involvement and indirectly by complicating ophthalmological examinations due to limited eye contact and poor cooperation. Visual impairments may exacerbate social interaction difficulties and affect motor development in individuals with ASD. Previous studies reported ophthalmological involvement in 27-71% of children with ASD, including refractive errors, strabismus, and amblyopia. The purpose...

Le Mon, 09 Feb 2026 06:00:00 -0500

Background: Adults with learning disabilities and autistic adults in England face significantly higher rates of premature mortality, 22 years earlier for those with learning disabilities and over 6 years earlier for autistic adults. Barriers to healthcare access contribute to missed diagnoses and treatments. There, the aim of this review was: What are the barriers and facilitators to healthcare appointment attendance for adults with learning disabilities and autistic adults in England? Methods:...

Le Mon, 09 Feb 2026 06:00:00 -0500

Psychedelics such as psilocybin, LSD, and MDMA have shown promise in treating mental health conditions (e.g., depression, post-traumatic stress disorder) among neurotypical individuals, i.e., typically developing individuals without a diagnosed neurodevelopmental condition. However, their therapeutic potential for treating co-occurring mental-health conditions in autistic individuals remains under-explored. Autistic individuals often face co-occurring mental health challenges but are frequently...

Le Mon, 09 Feb 2026 06:00:00 -0500

Mental health care for people diagnosed with autism is transforming towards recovery-oriented, person-centered network care. Within this changing landscape, the Open Dialogue approach is acknowledged as a promising approach that exemplifies this transformation. Characterized by its transparent and equitable collaboration between client, their network and mental health care professionals, the Open Dialogue approach shows promise for people diagnosed with autism but also poses potential...

Le Mon, 09 Feb 2026 06:00:00 -0500

Research and clinical practice that addresses the needs of Autistic children often de-centres minoritized voices, despite the existing inequities that prevents their access to services and community participation. Grounded in Disability Critical Race Theory, this scoping review sought to collate and synthesise the research on the intersecting lived experiences of Autistic children and families from racially and ethnically minoritized backgrounds to inform more culturally attuned paediatric...

Le Mon, 09 Feb 2026 06:00:00 -0500

Autistic children and young people are at increased risk of experiencing mental health difficulties, but often face delays or barriers to accessing support. While evidence exists regarding parents' experiences of supporting an autistic child, there is a lack of focus on parenting autistic children who are also experiencing mental health difficulties. This is despite the high likelihood of co-occurrence, the increased complexity this can bring, and the potential impact on the parents and their...

Le Mon, 09 Feb 2026 06:00:00 -0500

The parents of children with autism spectrum disorder face a mountain of practical problems. Helpful coping resources enable to restore equilibrium, otherwise, parents can perceive burden. The aim of the study was to find out the perceived burden and coping strategies among parents of children with autism spectrum disorder. This cross-sectional analytical study was conducted at Kanti Children's Hospital, Kathmandu, Nepal among 78 parents of children with autism spectrum disorder selected by...

Le Mon, 09 Feb 2026 06:00:00 -0500

Parent-mediated interventions (PMI) have demonstrated effectiveness in supporting autistic children's emotional regulation, social engagement, and communication. However, most research has focused on quantitative child outcomes, with limited attention to caregivers' lived experiences, particularly within non-Western urban contexts such as Hong Kong. This study explored how a culturally adapted PMI shaped caregiving practices and parent-child relationships among Hong Kong caregivers of autistic...

Le Mon, 09 Feb 2026 06:00:00 -0500

CONCLUSIONS AND RELEVANCE: In this study, individuals with ASD, ID, or CP experienced higher mortality from a range of causes compared with the general population in youth and young adulthood. Mortality among these groups is difficult to ascertain using death certificates alone, since ICD-10 codes for these disabilities were rarely listed. These findings can inform public health and health care strategies to understand and prevent health disparities and excess mortality associated with...

Le Mon, 09 Feb 2026 06:00:00 -0500

CONCLUSION: Identifying subgroups of children with higher prevalence of autism or greater co-occurring ID can inform public health policy and improve outcomes for individuals with autism and their families. Differences in prevalence and co-occurring ID by race/ethnicity may suggest barriers to service utilization.

Le Mon, 09 Feb 2026 06:00:00 -0500

CONCLUSION: These results add to the literature, positioning the BOSA as a promising, affordable, and adaptable tool for improving timely access to high-quality autism assessments in culturally and linguistically diverse, underserved communities. Additional research is needed to assess its usefulness in different circumstances while aiming to increase ease and efficiency of coding. The BOSA's suitability for use by non-specialists in intervention and school-based settings could help reduce...

Le Mon, 09 Feb 2026 06:00:00 -0500

CONCLUSION: This study highlights genetic heterogeneity in Indian ASD cases, identifying novel variants and pathways of potential biological relevance. Moderate GAS sample size and high variants of uncertain significance burden warrant further validation.