Le Mon, 01 Dec 2025 06:00:00 -0500

No abstract

Le Mon, 01 Dec 2025 06:00:00 -0500

Autism spectrum disorder (ASD) involves complex genetic-environmental interactions, with the gut microbiota (GM)-brain axis playing a key role. To explore whether the ASD risk gene Cntn4 contributes to disease development via gut-brain connectivity, our study employed a Cntn4 knockout mouse model. The microbial diversity and abundance in the gut contents of these mice were assessed using 16S rDNA sequencing, while metabolite changes in the gut contents, serum, and cerebral cortex were detected...

Le Mon, 01 Dec 2025 06:00:00 -0500

Understanding the developmental trajectory of autism spectrum disorder (ASD) remains a critical barrier for timely intervention in children. Here, we investigated the deficit brain maturation trajectory during childhood development in 35 ASD level 1 and 35 neurotypical children through an electroencephalography (EEG) approach. An empirical study of the potential EEG biomarkers was demonstrated in a comprehensive view of group difference and age-related group comparison using alpha power, peak...

Le Mon, 01 Dec 2025 06:00:00 -0500

CONCLUSION: This initiative addressed a key service gap for CALD families. The resource is now in routine use and will be translated into Arabic and Vietnamese. Parent feedback will directly inform the next codesigned iteration, which will improve content and multimodal delivery to meet the needs of diverse communities.

Le Mon, 01 Dec 2025 06:00:00 -0500

No abstract

Le Mon, 01 Dec 2025 06:00:00 -0500

No abstract

Le Mon, 01 Dec 2025 06:00:00 -0500

Emotion reactivity and regulation are implicated in the experience of anxiety and depression by autistic adults, but their measurement has been hindered by reliance on subjective judgment. Biological measurement methods may improve insight by offering a perspective beyond self/other-report. Using PRISMA guidelines, this systematic review aimed to (1) clarify current emotion reactivity and regulation measurement practices used with autistic adults, and (2) summarize conclusions on the autistic...

Le Mon, 01 Dec 2025 06:00:00 -0500

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes deficits in social interactions, communication skills, intellectual limitations, and self-injurious behaviors. Common systemic comorbidities include gastrointestinal issues, obesity, and cardiovascular disease. Recent study has found a link between gut microbiota alterations and neurobehavioral symptoms in children with ASD. Physical activity and exercise therapy have been demonstrated to promote communication and social...

Le Mon, 01 Dec 2025 06:00:00 -0500

INTRODUCTION: Differentiating Autism Spectrum Disorder (ASD) from Global Developmental Delay (GDD) in preschoolers may be challenging due to overlapping symptoms and shared developmental impairments. This study aimed to examine similarities and differences in adaptive functioning, emotional and behavioral characteristics, and autistic symptomatology in preschoolers with ASD and those with GDD presenting autistic traits.

Le Mon, 01 Dec 2025 06:00:00 -0500

Latino individuals with autism spectrum disorder (ASD) face unique challenges during their transition to adulthood. This study evaluates ¡Iniciando! la Adultez, a culturally adapted behavioral health program aimed at addressing the co-occurring mental health needs of Latino young adults with ASD and their families. The program integrates culturally relevant elements to enhance engagement and effectiveness. Results indicated that the behavioral health intervention was associated with significant...

Le Mon, 01 Dec 2025 06:00:00 -0500

CONCLUSION: Autistic people with complex communication needs must be included in research about the lived experiences of autistic people. Building on previous work, we show that, with dedication and imagination, equitable and inclusive research is possible.

Le Mon, 01 Dec 2025 06:00:00 -0500

CONCLUSIONS: These findings highlight the importance of diverse ancestries and early-life exposures in understanding ASD heterogeneity. Future research should replicate these findings in larger samples and explore rare variants associated with preterm birth to better understand the relationship between gestational duration and clinical and genetic differences in ASD.

Le Mon, 01 Dec 2025 06:00:00 -0500

The aim was to investigate effect of transcranial direct current stimulation (tPCS) on the neuropsychology of social functioning in children with autism spectrum disorder. It was expected that children with ASD randomly assigned to the experimental tPCS condition would show improvements in the neuropsychology of social functioning compared to those in the sham group. This study was a multicenter, double-blind, sham-controlled, randomized trial conducted at eight center for autism in Mecca, KSA....

Le Mon, 01 Dec 2025 06:00:00 -0500

This study examined how parents of children with and without an autism diagnosis respond to their children's negative emotions. Specifically, we (1) compared levels of supportive, non-supportive, and distress reactions; (2) tested whether child characteristics (autism traits and emotion dysregulation) predicted parent responses; and (3) explored whether autism diagnosis moderated these associations. Participants were 1780 parents of 2- to 5-year-old children from the United States (812 with an...

Le Mon, 01 Dec 2025 06:00:00 -0500

Compared with their non-licensed peers, licensed autistic adults appear to report more positive outcomes in objective measures of quality of life, particularly participation in activities outside of the home. We examined if this is due to individual differences/factors or the ability to independently drive. We conducted a prospective follow-up survey study of 16-21 years old in the United States and compared engagement in activities outside of the home over time by licensing status. Our final...