Modifié le 27/05/2024
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GABA(A) receptor dysfunction in autism spectrum disorder: molecular mechanisms and therapeutic opportunities
Le 24/06/2026
Autism spectrum disorder (ASD) comprises diverse neurodevelopmental trajectories in which altered circuit dynamics converge on a disturbance of excitation-inhibition balance. Genetic, postmortem, neuroimaging, and model-system evidence implicates γ-aminobutyric acid type A (GABA(A)) receptors as a major molecular node within this imbalance. ASD has been associated with changes in GABA(A) receptor subunit expression and assembly, notably within 15q11-q13 clusters, impaired receptor trafficking...
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Individualized Behavioral Management Techniques to Facilitate and Maintain Dental Treatment in a Child With Autism Spectrum Disorder: A Case Report
Le 24/06/2026
Autism spectrum disorder (ASD) presents significant challenges in dental practice due to impairments in communication, sensory processing, and behavioral regulation. This case report describes the management of a five-year-old male child with ASD who exhibited anxiety, hypersensitivity to auditory stimuli, and limited cooperation during dental visits. An individualized, non-pharmacological behavioral approach was implemented, including desensitization, the tell-show-do technique, non-verbal...
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Gut microbiome dynamics in autism: a prospective nested case-control study demonstrates microbial-clinical associations following rehabilitation interventions
Le 24/06/2026
CONCLUSION: This study demonstrates that rehabilitation intervention synchronously ameliorates clinical symptoms and modulates the gut-metabolic profile in ASD. The identified associations between specific metabolites (ornithine and tyrosine) and clinical outcomes suggest a metabolic mechanism underlying the gut-brain axis, highlighting the potential of these metabolites as biomarkers for therapeutic monitoring. Further large-scale studies are needed to validate these findings.
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Mental health disorders and suicide risk among autistic children, adolescents and adults: a population-based study using linked administrative data
Le 24/06/2026
BACKGROUND: Autistic people face elevated mental health risks, yet few population-based studies have quantified these risks across developmental stages. We examined the prevalence and relative risk of physician-diagnosed mental health disorders and suicide attempts among autistic individuals in the province of Manitoba, Canada, using linked administrative health data.
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Prdm15 Deficiency Results in Impaired Hippocampal Neurogenesis and Autism-Like Behaviors
Le 23/06/2026
Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder, with epidemiological studies consistently reporting a rising prevalence worldwide. Our previous human genetic sequencing analysis identified PRDM15 (PRDI-BF1 (Positive regulatory domain I-binding factor 1) and RIZ1 (Retinoblastoma protein-interacting zinc finger 1) homologous domain-containing protein 15), a transcriptional regulator and a member of the PRDM family, as a novel candidate risk gene for ASD....
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Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Turkiye
Le 23/06/2026
CONCLUSIONS: Severe mealtime behavioural dysregulation in ASD intrinsically compromises diet quality and elevates parental psychosocial burden. Clinical management requires a multidisciplinary, family-centred approach integrating behavioural feeding support with caregiver stress management.
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Reply to the Letter to the Editor on: impact of screen use on behavior and sleep in patients with autism spectrum disorder
Le 23/06/2026
No abstract
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Letter regarding "Impact of screen use on behavior and sleep in patients with autism spectrum disorder"
Le 23/06/2026
No abstract
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"I have to listen to whichever part of the body makes sense": A qualitative study of intuitive eating in autistic/AuDHD people
Le 23/06/2026
Intuitive eating, an adaptive approach to eating that involves listening to and trusting the body's internal cues, has been identified as an effective strategy for fostering a positive body image and enhancing physical and mental well-being. While body image scholars have extensively explored intuitive eating among the general population, extant theory and practice have yet to consider the neurodivergent community, specifically autistic/AuDHD people (autistic and have ADHD). To address this, we...
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Autism and Aphantasia
Le 23/06/2026
Aphantasia is characterised by an inability to have volitional imagined sensations. While initially characterised as an inability to visualise, Aphantasia is now regarded as having a multisensory profile, that can manifest in inabilities to have imagined sensations of sound, smell, taste, touch and of bodily sensations. Aphantasia has repeatedly been linked to autism - a neurodevelopmental condition that can shape how a person interacts with others and experiences the world. The strength of this...
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The Cardiac Safety of High-Dose Propranolol Used to Treat Severe Behaviors With Autism Spectrum Disorders
Le 23/06/2026
CONCLUSIONS: In our population, high-dose propranolol appeared to be safe from a cardiologic perspective. Our population skewed toward young individuals without preexisting heart pathology. We recommend its use with appropriate caution for any given individual.
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Camouflaging in autism as a dual-normative construct: a philosophical critique
Le 23/06/2026
Social camouflaging-broadly defined as the suppression or modulation of autistic traits to conform to dominant ableist social norms-has become a dominant construct in autism research. Yet despite its empirical and cultural prominence, the concept has not undergone sustained philosophical scrutiny. This paper develops a fourfold critique. Ontologically, camouflaging lacks stability, as it fails to identify a coherent class of phenomena distinguishable from adjacent behaviours. Epistemologically,...
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A Large-Scale Study on the Relation Between Multilingualism and Social Traits in Adults With and Without Autism Diagnoses
Le 23/06/2026
Autism Spectrum Disorder is a neurodevelopmental condition characterized by persistent difficulties in social interaction and communication alongside restricted, repetitive patterns of behavior, interests, or activities. Emerging evidence suggests that bi/multilingualism may enhance social interaction skills, yet prior research has largely focused on children, relied on small samples, and used oversimplified monolingual-bilingual groupings. The present study examines whether multilingual...
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Pediatric Residents' Knowledge and Confidence in Autism Diagnosis: Impact of an Asynchronous Training Module Embedded Within a Developmental-Behavioral Pediatrics Rotation
Le 23/06/2026
With rising autism prevalence coupled with a shortage of trained specialists, pediatricians are caring for more patients with autism. However, pediatric residents experience gaps in autism knowledge and comfort in caring for these children. This study aimed to evaluate changes in autism knowledge and perceived confidence among residents after completion of a developmental-behavioral pediatrics (DBP) rotation, which included an asynchronous module on autism diagnosis. Participants were 79...
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Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder
Le 23/06/2026
Heterogeneity is a critical factor in understanding inter-individual brain and behavioral variability in autism spectrum disorder (ASD). Since individuals with ASD exhibit atypical communication and social interaction skills closely linked to brain lateralization, this study investigated ASD heterogeneity using an asymmetry index that captures interhemispheric differences in brain function. Degree centrality was computed from the functional connectivity matrix, and its asymmetry was quantified...
