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Veille Pubmed

Modifié le 27/05/2024

Prior Diagnoses and Age of Diagnosis in Children Later Diagnosed with Autism

Le Mon, 25 Nov 2024 06:00:00 -0500

Awareness of autism is rising, yet social determinants of health impact ages of diagnosis, and diagnostic load. Unequal rates of diagnoses may indicate biases in the healthcare system. This study investigates six prior diagnoses (ADHD, conduct, adjustment, anxiety, mood, and intellectual disability) assigned to children who are later diagnosed with autism. The study investigates how race, sex, and geographic factors were associated with age of diagnosis and diagnostic load. A sample of 13,850...

Salivary IL-1 Beta Level Associated with Poor Sleep Quality in Children/Adolescents with Autism Spectrum Disorder

Le Mon, 25 Nov 2024 06:00:00 -0500

CONCLUSIONS: Children and adolescents with ASD showed significantly poorer sleep quality based on their parents' reports compared to the TD group, and the salivary IL-1 beta concentration was inversely associated with sleep quality only in the ASD group. Further studies on the associations between inflammatory cytokines and sleep in ASD are needed.

Sex Differences in Sleep and Physical Activity Patterns in Autism Spectrum Disorder

Le Mon, 25 Nov 2024 06:00:00 -0500

Physical activity (PA) programs have been found to result in improved sleep in males with autism spectrum disorder (ASD), but little is known about the female characteristics. The aim of this work was to assess sex differences in sleep and PA indices using an accelerometer over 7 days and 7 nights. Sleep and PA variables were measured with questionnaires and with accelerometry in twenty-four children with ASD (16 boys, 10.3 ± 2.8; 8 girls, 11.1 ± 3.9). Some significant differences were reported...

Prevalence of autism spectrum disorder diagnosed according to DSM-5 criteria and associated factors in preschoolers in southern Vietnam

Le Mon, 25 Nov 2024 06:00:00 -0500

CONCLUSION: ASD represents a significant pediatric psychiatric issue in southern Vietnam, with a higher incidence than previously reported. Some of the identified risk factors are potentially preventable, suggesting that targeted interventions could reduce the incidence of ASD.

Expression Levels of miR -124a, miR-545-3p and BDNF in the Peripheral Blood Mononuclear Cells Are Associated with the Severity of Autism

Le Mon, 25 Nov 2024 06:00:00 -0500

CONCLUSIONS: Deregulation of miR-124a, miR-454-3p and BDNF might be considered as potential biomarkers for severity of autism.

Methods to reduce fraudulent participation and highlight autistic voices in research

Le Mon, 25 Nov 2024 06:00:00 -0500

Over the last decade, especially since the pandemic, more research has been happening online. Conducting research online can create opportunities to include autistic people across the world and make our studies more diverse. However, conducting research online had led to scammers, or people pretending to be autistic, participating in autism research studies. Strategies to stop scammers may accidentally leave out autistic people who have difficulty with processing time and open-ended questions....

'I'm sick of being the problem': Autistic mothers' experiences of interacting with schools for their autistic children

Le Mon, 25 Nov 2024 06:00:00 -0500

Good relationships between families and schools make a difference to children's learning - and the same goes for autistic children. But parents of autistic children often find it very stressful interacting with teachers and school staff. In this study, we focused on autistic parents of autistic children. We wanted to know about their experiences of interacting with schools and the impact these had on them and their children. We spoke to 31 autistic mothers of autistic children about their...

Maternal immune activation and autism in the offspring-what is the evidence for causation?

Le Sun, 24 Nov 2024 06:00:00 -0500

The maternal immune activation hypothesis has gained attention over the past two decades as a potential contributor to the etiology of autism. This hypothesis posits that maternal conditions associated with inflammation during pregnancy may increase the risk of autism in offspring. Autism is highly heritable, and causal environmental contributors to autism largely remain elusive. We review studies on maternal conditions during pregnancy, all associated with some degree of systemic inflammation;...

Family Resilience in Families of Children With Autism Spectrum Disorders: Ecological Systems Theory Perspective

Le Sun, 24 Nov 2024 06:00:00 -0500

Drawing on Bronfenbrenner's ecological systems theory (1992), we asked how certain resources contribute to family resilience in families of children with ASD: family quality of life (FQOL; family resources), sense of community and loneliness (informal resources), and family-centered support provided by the state (formal resources). One hundred and twenty-one Israeli parents of children with ASD completed an online survey. Path analysis using AMOS was conducted. FQOL contributed to increased...

Identification of autism spectrum disorder using electroencephalography and machine learning: a review

Le Sun, 24 Nov 2024 06:00:00 -0500

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by communication barriers, societal disengagement, and monotonous actions. Traditional diagnostic methods for ASD rely on clinical observations and behavioural assessments, which are time -consuming. In recent years, researchers have focused mainly on the early diagnosis of ASD due to the unavailability of recognised causes and the lack of permanent curative solutions. Electroencephalography (EEG) research in ASD...

"I Know it's Good to Do it": A Qualitative Study Exploring the Perspective of Autistic Men on Social Motivation

Le Sun, 24 Nov 2024 06:00:00 -0500

The social motivation hypothesis states that people with Autism Spectrum Condition (ASC) have a diminished social motivation, that is (1) less priority in attention for objects of social importance, (2) diminished social reward, and (3) less desire to maintain and strengthen relationships. Little is known about the perception of autistic people on their social motivation. This study used semi-structured interviews to explore how eleven autistic men perceived their social motivation, behaviour,...

Risk assessment and automatic identification of autistic children based on appearance

Le Sat, 23 Nov 2024 06:00:00 -0500

The diagnosis of Autism Spectrum Disorder (ASD) is mainly based on some diagnostic scales and evaluations by professional doctors, which may have limitations such as subjectivity, time, and cost. This research introduces a novel assessment and auto-identification approach for autistic children based on the appearance of children, which is a relatively objective, fast, and cost-effective approach. Initially, a custom social interaction scenario was developed, followed by a facial data set (ACFD)...

Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue

Le Sat, 23 Nov 2024 06:00:00 -0500

Autism spectrum disorder (ASD) often co-occurs with functional somatic syndromes (FSS), such as irritable bowel syndrome (IBS), multisite pain, and fatigue. However, the underlying genetic mechanisms and causality have not been well studied. Using large-scale genome-wide association study (GWAS) data, we investigated the shared genetic architecture and causality between ASD and FSS. Specifically, we first estimated genetic correlations and then conducted a multi-trait analysis of GWAS (MTAG) to...

A Natural History Study of Timothy Syndrome

Le Sat, 23 Nov 2024 06:00:00 -0500

CONCLUSIONS: This study represents the first Natural History Study of Timothy syndrome, offering a comprehensive overview of the disease's clinical manifestations. We demonstrate that both cardiac and extra-cardiac features are prevalent across all patient groups, underscoring the syndromic nature of CACNA1C variants. While the critical role of long QT syndrome and cardiac arrhythmias in Timothy syndrome has been well recognized, our findings indicate that hypoglycemia and respiratory...

Potential key pathophysiological participant and treatment target in autism spectrum disorder: Microglia

Le Sat, 23 Nov 2024 06:00:00 -0500

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by social and communication deficits, as well as restricted or repetitive behaviors or interests. Although the etiology of ASD remains unclear, there is abundant evidence suggesting that microglial dysfunction is likely to be a significant factor in the pathophysiology of ASD. Microglia, the primary innate immune cells in the central nervous system (CNS), play a crucial role in brain development and...

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