Le Fri, 20 Jun 2025 06:00:00 -0400

Refining the classification of autism spectrum disorder (ASD) subtypes is essential for advancing personalized interventions strategies, given the substantial heterogeneity in phenotypic clinical symptoms among individuals with ASD. Thus, the current study integrated normative modeling, resting-state fMRI data, clinical assessment, and eye-gaze patterns to investigate potential ASD subtypes. By incorporating both static and instant dynamic (strength and variability) functional connectivity as...

Le Fri, 20 Jun 2025 06:00:00 -0400

Attenuated interpersonal synchrony (IPS) has been shown between autistic individuals and their interaction partners; however, the mechanisms of this attenuation remain unclear. One possibility could lie in perceiving the timing of others' behaviors. The present study aimed to relate the behavioral production of IPS with the perception of temporal dynamics of social interactions and event timing perception in autistic and non-autistic adults. Autistic and non-autistic participants engaged in...

Le Fri, 20 Jun 2025 06:00:00 -0400

No abstract

Le Fri, 20 Jun 2025 06:00:00 -0400

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social deficits, restricted interests, and repetitive behaviors. Although aripiprazole and risperidone are FDA-approved for ASD, they primarily target comorbid symptoms and are associated with significant side effects. This study aimed to investigate the effects of 6-bromoindirubin-3'-oxime (6BIO), a glycogen synthase kinase 3β (GSK3β) inhibitor, in a VPA model of ASD. Pregnant Wistar rat dams received a...

Le Fri, 20 Jun 2025 06:00:00 -0400

CONCLUSION: Our findings indicate that the MBSSR program effectively supports parents in coping with stigma and yields a wide range of benefits, simultaneously improving their mental health, caregiving perceptions, interpersonal mindfulness in parenting, and child clinical outcomes. Given these benefits, practitioners should consider integrating mindfulness training-such as the MBSSR program-into support services for families of autistic children.

Le Fri, 20 Jun 2025 06:00:00 -0400

Caregiver-mediated supports in general have shown mixed evidence for enhancing language outcomes in infants at higher likelihood of autism. While caregivers play a substantial role in caregiver-mediated supports, little is known about whether caregivers' own subclinical autistic features - known as broader autism phenotype (BAP) - may moderate infant language outcomes. In secondary analysis of trial data, we examined whether caregiver BAP moderated the effectiveness of the iBASIS...

Le Fri, 20 Jun 2025 06:00:00 -0400

CONCLUSIONS: These findings have important implications for research and practice for young autistic children. There is a need for educators and other practitioners to (a) assess emergent literacy skills in early childhood to better identify autistic children who are at risk for reading difficulties and (b) actively promote and teach emergent literacy skills in young autistic children, as these skills are related to more advanced reading abilities.

Le Fri, 20 Jun 2025 06:00:00 -0400

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic component that is becoming increasingly prevalent. The identification of plasma molecular biomarkers may provide potential insights into ASD and aid in early diagnosis. In this study, we characterized the metabolomic profiles of ASD children using blood spot samples collected at the Children's Hospital of Zhejiang University School of Medicine from children with ASD (n = 43) and typically developing (TD)...

Le Fri, 20 Jun 2025 06:00:00 -0400

No abstract

Le Fri, 20 Jun 2025 06:00:00 -0400

No abstract

Le Fri, 20 Jun 2025 06:00:00 -0400

Racial and ethnic minority autistic transition-aged youth and young adults (TAYA) experience a range of barriers to optimal health, development, and thriving. These barriers are related to challenges associated with this distinct developmental period, as well as experiences linked to their multiple marginalized intersectional identities. Currently, there is a need for additional research that can spur the development and dissemination of critical supports for this population. In the current...

Le Fri, 20 Jun 2025 06:00:00 -0400

CONCLUSION: Results of this study suggest self-consenting Autistic adults face significant barriers to voting and have unique experiences related to political participation. Future research to improve and support political participation among Autistic adults is a critical research priority.

Le Fri, 20 Jun 2025 06:00:00 -0400

BACKGROUND: The quality of life (QoL) of Autistic people is consistently reported to be poor compared with the general population. Little is known, however, about how Autistic people experience QoL from their perspectives and the ways they would like it to be enhanced. This qualitative study, conducted in collaboration with Autistic people, sought to understand how Autistic young people and adults define a good life and what helps and hinders them from achieving a good QoL.

Le Fri, 20 Jun 2025 06:00:00 -0400

CONCLUSIONS: We show that autistic social media users have specific preferences in how they communicate and express connection online. However, due to negative experiences of social interactions some do not follow these preferences and instead select linguistic and visual resources that can reduce perceived risks of misunderstanding. We question the claims that the internet is inherently enabling for autistic users and call for further research and policy effort to ensure autistic sociality...

Le Fri, 20 Jun 2025 06:00:00 -0400

CONCLUSIONS: The findings of this research provide greater insight into the mental health experiences of autistic adults and can inform the development of tailored interventions that target camouflaging and self-compassion.