Le Tue, 26 Aug 2025 06:00:00 -0400

CONCLUSION: The transcription - neuroimaging associations arising from cerebral perfusion redistribution in ASD are supplemented in an additional way, which helps in enhancing the understanding of the ASD brain.

Le Tue, 26 Aug 2025 06:00:00 -0400

Many adults express dissatisfaction with the autism diagnostic process, and concerns have been cited regarding the lack of neurodiversity-affirming assessment methods. In part, this is due to instruments framing behaviors as symptoms causing impairment, overlooking potential benefits. Systematically measuring strengths and talents during assessment may inform diagnosis and support planning in a more neurodiversity-affirming manner. Historically, research has relied on caregiver-reported...

Le Tue, 26 Aug 2025 06:00:00 -0400

Biological accounts have suggested an overlap between Parkinson's disease and autism despite their being studied largely at opposite ends of the life course. Characterising this overlap can identify potentially shared aetiologies and care pathways for these conditions. However, this overlap has so far only been tested in older autistic adults who show greater Parkinson's disease traits. The converse has not been directly assayed, that is, if adults with Parkinson's disease have higher autistic...

Le Tue, 26 Aug 2025 06:00:00 -0400

CONCLUSIONS: We describe a novel neurodevelopmental disorder with spastic paraparesis and a high carrier rate in the Ashkenazi Jewish population. Our results indicate that TBCB has a vital role in CNS development and potentially in axonal function in humans.

Le Tue, 26 Aug 2025 06:00:00 -0400

CONCLUSION: This study showed that both Queensland specialists in pediatric dentistry and SCD find social stories to be a useful tool in the management of patients with autism. Further research would enable greater insights into the perception of social stories among dental specialists across Australia.

Le Mon, 25 Aug 2025 06:00:00 -0400

CONCLUSION: Labor induction was associated with a higher ASD incidence but not as an independent risk factor after adjusting for maternal and perinatal factors.

Le Mon, 25 Aug 2025 06:00:00 -0400

BCL11A encodes a transcription factor essential for brain development, with pathogenic variants causing intellectual disability, autism spectrum disorder (ASD), microcephaly, hypotonia, and behavioral abnormalities. While clinical studies have identified cerebellar pathology in patients with BCL11A variants, the specific roles of this gene in cerebellar function and its relationship to clinical symptoms remain unclear. In this study, we demonstrate that Bcl11a is predominantly expressed in...

Le Mon, 25 Aug 2025 06:00:00 -0400

CONCLUSIONS: Diagnostic inequities in ASD and other mental disorders persist across US patient populations. Multiple factors such as parental health literacy, provider bias and limited access interact and impact the diagnostic process. Addressing these interconnected barriers is essential to ensure timely, accurate and equitable care.

Le Mon, 25 Aug 2025 06:00:00 -0400

CONCLUSIONS: CB1R/CB2R activation ameliorates behavioral abnormalities and rectifies hippocampal lipid dysregulation in VPA-induced ASD models, highlighting cannabinoid receptors as potential therapeutic targets for ASD-associated metabolic disturbances.

Le Mon, 25 Aug 2025 06:00:00 -0400

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interaction, communication deficits, and repetitive behaviors. However, the underlying molecular mechanisms remain elusive. This study aims to investigate the role of cyclin-dependent kinase inhibitor 1 A (CDKN1A) in ASD. This study integrated multi-omics bioinformatics analysis to identify differentially expressed genes (DEGs) related to oxidative stress in ASD. Hub genes were screened...

Le Mon, 25 Aug 2025 06:00:00 -0400

CONCLUSION: Although there is evidence suggesting a link between screen time and ASD, the relationship remains unclear; further research is needed to better understand these connections and develop effective interventions for children with this disorder.

Le Mon, 25 Aug 2025 06:00:00 -0400

CONCLUSION: The diagnosis of BCKDK deficiency should be suspected in patients with NDD and autism, and BCAA supplementation should be initiated as soon as diagnosis confirmation to prevent irreversible brain damage. The results emphasize that early diagnosis and dietary intervention by regulating plasma BCAA levels lead to the prevention of irreversible neurodevelopmental implications.

Le Mon, 25 Aug 2025 06:00:00 -0400

The Facial Action Coding System (FACS) has been used by numerous studies to investigate the links between facial behavior and mental health. The laborious and costly process of FACS coding has motivated the development of machine learning frameworks for Action Unit (AU) detection. Despite intense efforts spanning three decades, the detection accuracy for many AUs is considered to be below the threshold needed for behavioral research. Also, many AUs are excluded altogether, making it impossible...

Le Sun, 24 Aug 2025 06:00:00 -0400

CONCLUSIONS: These findings highlight the critical role of healthcare accessibility and environmental factors in shaping the relationship between air pollution and ASD severity. Integrating geographic and environmental contexts is crucial when evaluating the environmental determinants of ASD outcomes.

Le Fri, 22 Aug 2025 06:00:00 -0400

CONCLUSIONS: Findings advance our understanding of JA linked with autism traits in adulthood and showcase the feasibility of interactive eye-tracking methodologies in JA research. Limitations and implications for research are discussed.