Le Thu, 02 Oct 2025 06:00:00 -0400

No abstract

Le Thu, 02 Oct 2025 06:00:00 -0400

The gut microbiota plays a crucial role in human health, with growing evidence linking its composition to the development of Autism Spectrum Disorder. However, inconsistencies in previous studies have hindered the identification of a definitive microbial signature associated with Autism Spectrum Disorder. Machine learning models have emerged as powerful tools for analyzing microbiome data, yet their interpretability remains limited. In this study, we integrate in silico simulations with machine...

Le Thu, 02 Oct 2025 06:00:00 -0400

The hippocampus plays a crucial role in memory and social processing, both of which are impaired in autism spectrum disorder (ASD). Investigating the functional activity of hippocampal subregions can provide valuable insights into their involvement in ASD-related social and behavioral symptoms. This study analyzed hippocampal resting-state functional connectivity (rsFC) in 507 male child participants from the ABIDE dataset (225 ASD, 282 typical controls) and its relation to clinical features....

Le Thu, 02 Oct 2025 06:00:00 -0400

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulty with communication and social interactions as well as restricted or repetitive behaviors. Over the last few decades, the prevalence of ASD has increased globally, with major differences in reporting, diagnosis, and interventions between developed and developing countries. The United States (U.S.) has seen a sharp rise in diagnosed ASD cases, with a current prevalence of approximately 1 in 31 children,...

Le Thu, 02 Oct 2025 06:00:00 -0400

BACKGROUND: One of the most important demographic challenges in the world over the last three decades has been the significant decline in fertility rates. Fertility decision making is one of the major events in a couple's life and can be a complex process, especially for families who have a child with a history of a multifactorial disease, such as autism spectrum disorder. Therefore, the present study will be aim to discover the childbearing decision-making process in mothers of children with...

Le Thu, 02 Oct 2025 06:00:00 -0400

No abstract

Le Wed, 01 Oct 2025 06:00:00 -0400

CONCLUSIONS: Taken together, our results highlight the importance of autistic features in the psychosis spectrum. It is clear that there is a significant gap in clinical knowledge regarding the relationship between autism and psychosis and that further improvements in diagnostic tools and treatment options are needed. As our study is cross-sectional in design, speculation about causality is limited and further prospective research is needed.

Le Wed, 01 Oct 2025 06:00:00 -0400

No abstract

Le Wed, 01 Oct 2025 06:00:00 -0400

No abstract

Le Wed, 01 Oct 2025 06:00:00 -0400

Although autism has historically been conceptualized as a condition that emerges in early childhood^(1,2), many autistic people are diagnosed later in life^(3-5). It is unknown whether earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles. Using longitudinal data from four independent birth cohorts, we demonstrate that two different socioemotional and behavioural trajectories are associated with age at diagnosis. In independent cohorts of autistic...

Le Wed, 01 Oct 2025 06:00:00 -0400

Autistic diagnosis and sensory tests present subjectivity, temporal behaviors, and vagueness. In the autistic sensory classification model, Recurrent Neural Networks (RNNs) and Long Short-Term Memory (LSTM) networks are considered for temporal sensory response patterns learning. To alleviate these challenges, we introduced an original hybrid framework that combines double hierarchy hesitant linguistic term sets (DHHLTS), temporal Three-Way Decision-Making (TWD). There are essentially three...

Le Wed, 01 Oct 2025 06:00:00 -0400

Early detection of Autism Spectrum Disorder (ASD) in children is crucial for timely interventions that can improve developmental outcomes. Traditional diagnostic methods are often resource-intensive, time-consuming, and may raise ethical concerns regarding privacy, particularly for minors. In this study, we evaluate the feasibility of privacy-preserving machine learning models for ASD detection using children's speech transcripts. By exclusively leveraging structured text-based inputs, our...

Le Wed, 01 Oct 2025 06:00:00 -0400

INTRODUCTION: Care (Education) and Treatment Reviews (C(E)TRs) are intended to reduce unnecessary psychiatric hospital admission and length of stay for people with intellectual disability and autistic people. The use and impact of C(E)TRs have not been systematically evaluated since their introduction in England in 2015. The aims of this study are to describe the demographic and clinical profiles of people who receive a community C(E)TR and to investigate their effects on admission, length of...

Le Wed, 01 Oct 2025 06:00:00 -0400

No abstract

Le Wed, 01 Oct 2025 06:00:00 -0400

CONCLUSIONS AND RELEVANCE: In this trial, memantine was well tolerated and significantly improved social impairments in youths with ASD. Elevated pgACC glutamate levels were associated with a favorable treatment response, supporting their potential as a biomarker for assessing memantine efficacy in individuals with ASD.