Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSIONS: Families of autistic ICU patients navigate multifaceted roles as advocates, interpreters and emotional supports within a culturally complex landscape. Their experiences reflect a need for more inclusive, autism-informed and family-centred critical care practices that respect both neurodiversity and cultural context.

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: Autism is an independent risk factor for having a prolonged ED stay, for boarding in the ED, and for prolonged ED boarding when presenting to the ED with a mental health crisis that requires hospitalization.

Le Tue, 02 Dec 2025 06:00:00 -0500

The ability to understand and share others' emotional states (e.g., feeling of pain) plays a fundamental role in survival and prosocial behavior. The current study utilized pupillometry to assess automatic psychophysiological responses to others' painful facial expressions in both adults and children (N = 72). Results revealed that pupil size significantly increased when perceiving painful versus neutral expressions, independent of low-level visual features. Notably, both adults and children...

Le Tue, 02 Dec 2025 06:00:00 -0500

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose rising prevalence places increasing demands on a lengthy diagnostic process. Machine learning (ML) has shown promise in automating ASD diagnosis, but most existing models operate as black boxes and are typically trained on a single dataset, limiting their generalizability. In this study, we introduce a transparent and interpretable ML approach that leverages BioBERT, a state-of-the-art language model, to analyze...

Le Tue, 02 Dec 2025 06:00:00 -0500

Thyroid hormones supplied by the mother are essential for fetal brain development but could be disrupted by per- and polyfluoroalkyl substances (PFAS). We explored how prenatal PFAS exposures relate to maternal thyroid function in pregnant participants from the MARBLES cohort. We analyzed 212 serum samples from 151 pregnant women who later had a child with diagnosis of autism spectrum disorder (ASD), nontypical development (non-TD), or typical development (TD) by age 3. We quantified nine PFAS,...

Le Tue, 02 Dec 2025 06:00:00 -0500

Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined neurodevelopmental conditions influenced by both genetic and environmental factors. Here, we show that supplementation of multiple low-dose nutrients-an important environmental factor contributing to ASD-can modulate synaptic proteomes, reconfigure neural ensembles, and improve social behaviors in mice. First, we used Tbr1+/- mice, a well-established model of ASD, to investigate the effect of nutrient cocktails...

Le Tue, 02 Dec 2025 06:00:00 -0500

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Le Tue, 02 Dec 2025 06:00:00 -0500

No abstract

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: The present study supported the empathy imbalance hypothesis in young children with ASD and might indicate that children with ASD have distinct neural characteristics related to cognitive empathy and affective empathy processing. Future studies can combine eye movement measurements while watching animations, and further longitudinal studies on the electrophysiological characteristics of empathy in children with ASD.

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: These findings add to our understanding of the characteristics of children who are at risk of profound autism. These findings have implications for clinical practice, including informing assessment processes, need for longitudinal follow up assessment, support planning and helping diagnosticians determine the appropriate level of support needed. Furthermore, these findings support calls for consideration of this group in policy planning, funding and earlier service access and ongoing...

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: The research findings indicate that parental encouragement and perceived ease of participation are key factors associated with physical activity in children with ASD.

Le Tue, 02 Dec 2025 06:00:00 -0500

No abstract

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: These findings highlight the need to address both genetic and environmental factors in ASD aetiology. Promoting healthy maternal habits and reducing harmful environmental exposures could potentially reduce ASD risk. Future research should focus on larger sample sizes and longitudinal studies to validate these findings and develop targeted interventions.

Le Tue, 02 Dec 2025 06:00:00 -0500

CONCLUSION: Children with ASD and ADHD showed significant sleep disturbance than children in control group. This study highlights the relationship between the impact of sleep disturbance and the problems associated with neurodevelopmental disorders. These findings emphasize the importance of assessment of sleep habit along with routine oral examination into the pediatric dental practice.

Le Tue, 02 Dec 2025 06:00:00 -0500

Autistic adults face higher rates of loneliness and depression than non-autistic adults. Self-compassion may offer a protective buffer against mental health difficulties, but its measurement validity and interaction with loneliness have not been studied in autistic populations. This two-part study examined (1) the dimensional structure of the Self-Compassion Scale (SCS) in a global sample of autistic (n = 377) and non-autistic (n = 196) adults, and (2) whether self-compassion moderates the...