Modifié le 27/05/2024
Le Tue, 27 Jan 2026 06:00:00 -0500
Compared with infants born at term, infants born preterm are more likely to develop autism spectrum disorder (ASD), but specific risk factors remain uncertain. To identify possible risk factors associated with ASD development in infants born preterm. We systematically searched PubMed, Embase, Web of Science, CINAHL and Scopus to May 2025 for observational studies reporting ASD in infants born preterm. Meta-analyses used RevMan 5.4 and Stata 14.0. We assessed certainty of the evidence using the...
Le Tue, 27 Jan 2026 06:00:00 -0500
Neuronal development relies on cell-surface glycoconjugates that function as complex bioinformational codes. Recently, altered glycosylation has emerged as a central mechanistic theme in the pathophysiology of autism spectrum disorder (ASD). Critically, the brain maintains a distinctively restricted glycan profile through strict biosynthetic regulation, creating a specialized landscape highly susceptible to homeostatic perturbation. This "membrane-centric vulnerability" spans both glycoproteins...
Le Tue, 27 Jan 2026 06:00:00 -0500
Autism spectrum disorder (ASD) and intellectual disability (ID) frequently coexist and share heterogeneous cognitive manifestations, yet their specific performance patterns on Wechsler scales remain poorly systematized. This meta-analysis synthesized data from 31 studies using the WISC-IV, WISC-V, WAIS-III, and WAIS-IV to compare cognitive index profiles in individuals with ASD, ID and ASD+ID. Standardized mean differences (Hedges' g) were calculated using random-effects models, adopting a...
Le Tue, 27 Jan 2026 06:00:00 -0500
Parental stress influences parent-child interactions in typical development and is a prognostic factor of autism outcome. However, we still do not know to what extent parental stress affects parent-child interactions and whether caregiver role matters. This study explored the relationship between parental stress and prosodic synchrony in parent-child vocal interactions, drawing on complex dynamic systems and affective computing frameworks. We assessed 62 dyads (31 autistic preschoolers,...
Le Tue, 27 Jan 2026 06:00:00 -0500
CONCLUSION: This study demonstrates consistently low rates of DCD diagnosis across 2 periods: before and after the publication of the DSM-5. Despite a modest increase, the prevalence of ASD + DCD co-diagnoses after the introduction of DSM-5, DCD rates remain significantly lower than reported in the literature. This discrepancy suggests significant and persistent underdiagnosis of DCD in children with ASD in British Columbia.
Le Tue, 27 Jan 2026 06:00:00 -0500
CONCLUSIONS: These findings highlight the need for further research into the developmental trajectories and communicative strategies of autistic bimodal bilingual children.
Le Mon, 26 Jan 2026 06:00:00 -0500
Autism spectrum disorder (ASD) and psychosis are traditionally considered distinct psychiatric conditions with divergent developmental trajectories, yet emerging evidence suggests they may share overlapping neurodevelopmental characteristics. This study examined whether the cognitive profile associated with co-occurring autism and first-episode psychosis (FEP) reflects additive or interactive influences of the two conditions. Neuropsychological profiles were compared across four age-, sex-,...
Le Mon, 26 Jan 2026 06:00:00 -0500
Families caring for children with autism spectrum disorder (ASD) often encounter persistent stress, stigma, and limited support systems. Despite these challenges, many demonstrate resilience-the capacity to adapt and sustain well-being under adversity. This integrative review synthesizes conceptual frameworks and interventions designed to strengthen family resilience in ASD caregiving. A systematic search across PubMed, Scopus, CINAHL, and Google Scholar (2000-2025) yielded 55 eligible studies....
Le Mon, 26 Jan 2026 06:00:00 -0500
When an autistic person requires inpatient mental health support, they should be supported in mainstream services with reasonable adjustments. However, there is a lack of research into how autistic service users find their admissions to mental health wards. Ten United Kingdom-based autistic adults took part in semi-structured interviews to explore their experiences of being a mental health inpatient. These results were analysed using reflexive thematic analysis (RTA) and four themes were...
Le Mon, 26 Jan 2026 06:00:00 -0500
This study aimed to identify guiding principles to underpin assessment and diagnosis of autism to improve the quality, consistency and accuracy of services provided to individuals and their families. An online survey and focus groups were used to capture community perspectives of members of the Australian autistic and autism communities. A total of 871 individuals participated across the research activities, including autistic individuals (n = 253), parents of autistic individuals (n = 344),...
Le Mon, 26 Jan 2026 06:00:00 -0500
In this article, we describe a combined dataset from three experiments on auditory attention and distraction in young adult individuals with Autism Spectrum Disorder (ASD) and nonautisitic individuals. In Experiment 1, we investigated the effects of steady-state, changing-state, and auditory deviant sounds on visual-verbal serial recall with list length adjusted individually to each participant. In Experiment 2, we investigated the effects of low- and high-intensity single-channel, dual-channel,...
Le Mon, 26 Jan 2026 06:00:00 -0500
Minimally-verbal autism is well described in hearing populations, but little is known about minimally-signing autism in deaf children with early, full access to sign. This case series presents seven deaf autistic children born to Deaf parents and exposed to American Sign Language (ASL) from birth who nonetheless remain minimally expressive signers. Participants were drawn from a nationwide cohort of 23 native-ASL deaf children with autism. Four children completed the Autism Diagnostic...
Le Mon, 26 Jan 2026 06:00:00 -0500
Limited access to specialist services, driven by workforce shortages and increasing demand, has constrained timely face-to-face management of autism spectrum disorder (ASD). Children and adolescents with ASD frequently engage with digital technologies, prompting growing interest in digital health interventions as potential adjuncts to traditional care; however, their effectiveness remains uncertain. This systematic review aimed to evaluate the evidence from randomised controlled trials assessing...
Le Mon, 26 Jan 2026 06:00:00 -0500
Autism can be defined as a neurodevelopmental learning difficulty characterised by deficits in social communication, the presence of restrictive interests and repetitive behaviours. The aim of this systematic review was to explore pedagogical practices and identify interventions that would have an impact on autistic medical students' experiences. A search strategy was undertaken on databases relevant to medical education. Included studies pertained to autistic medical students and/or...
Le Mon, 26 Jan 2026 06:00:00 -0500
CONCLUSION: These data indicate that regulators of the Wnt/β-catenin pathway, notably Dkk-1 and PORCN may play a potential role in the pathogenesis of ASD. This study presents new data confirming the significance of Wnt/β-catenin pathway regulators in ASD and underscores the necessity for further research.
