Le 07/05/2026

CONCLUSION: The findings highlight the importance of the examination of PPRs as a screening tool for children. Comprehensive investigation of PPRs, particularly in children with ASD, may contribute to a more accurate assessment of problems and higher effectiveness of possible intervention programs.

Le 07/05/2026

CONCLUSIONS: In medication-naïve children with ASD aged 18-72 months, peripheral BDNF is reduced and relates to symptom severity and adaptive/social difficulties, whereas other neurotrophic factors and basal HPA-axis hormones do not differ from controls. Longitudinal studies incorporating standardized sampling and diurnal/stress-reactivity indices are needed to clarify developmental dynamics and clinical implications.

Le 07/05/2026

Research examining family relationships in families with autistic members remains limited, and integrative frameworks that translate evidence into family focused practice are scarce. Existing interventions often prioritise individual symptom management rather than strengthening family relationships and connectedness. This article presents an evidence informed practice model designed to enhance relationships and connectedness in families of autistic adolescents, grounded in systems theory. The...

Le 07/05/2026

This scoping review synthesizes empirical research on how autistic family members shape family dynamics across relational subsystems, cultural contexts, and developmental stages. A comprehensive search conducted in January 2025 across five databases using the SPIDER framework yielded 102 studies analysed through convergent integrated three-stage thematic analysis informed by family systems theory. Five interconnected themes emerged: family identity reconstruction and role adaptation; emotional...

Le 07/05/2026

CONCLUSION: The severity of autism spectrum disorder and sex are not associated with the occurrence or severity of dental trauma among children. These findings suggest that factors beyond the severity of autism may play a more significant role in the risk and impact of dental trauma in this population. A clearer understanding of additional contributing variables is essential to inform more effective prevention and management strategies for high-risk individuals within this population.

Le 07/05/2026

CONCLUSION: Through this case study, we seek to share our experiences in developing a cross-sectoral health program and to inspire health professionals and policy makers to consider intervening at social systems for systemic changes in communities. We acknowledge that the development, implementation, and sustainability of our strategies require multidisciplinary expertise and financial investment, and this calls for strategic planning, community-wide participation, and shared ownership.

Le 07/05/2026

INTRODUCTION: Chinese American families of autistic children remain underrepresented in the autism intervention literature.

Le 07/05/2026

Sensory processing is a common target in autism spectrum disorder (ASD) research, yet the latent structure of sensory experience is disputed. Researchers frequently explore the presence of "subtypes" to categorize sensory heterogeneity, but such discrete models can fail to capture the intrinsic geometry of phenotypic data. In this study, we aim to characterize heterogeneous sensory profiles in ASD and explore if the same characterization can describe neurobiological function. First, we apply...

Le 07/05/2026

On September 22, 2025, the United States government announced that the Food and Drug Administration (FDA) would modify paracetamol (acetaminophen) labelling to warn of possible associations with autism, advising pregnant individuals to avoid the medication. This contradicts professional medical consensus and high-quality evidence, replicating communication failures of the 1998 MMR-autism controversy that caused vaccine hesitancy, disease outbreaks, and trust erosion. This narrative review...

Le 07/05/2026

Social anxiety (SA) is highly prevalent among autistic adults, yet little is known about how autistic people respond to common therapeutic strategies, such as exposure tasks. This study examined responses to a structured speech exposure task embedded within an 8-week modified cognitive-behavioral therapy (M-CBT) program. Thirty-two autistic adults with co-occurring SA completed pre- and post-task assessments of anxiety and related cognitive appraisals, including self-focused attention, perceived...

Le 07/05/2026

CONCLUSIONS: In this large prospective cohort, adverse long-term outcomes following maternal primary infection were observed only after first trimester exposure. Autism spectrum disorder occurred exclusively in this group and was consistently associated with temporal lobe white matter abnormalities. These findings support a time-restricted window of fetal vulnerability to CMV-related brain injury and suggest that neuroimaging findings may contribute to prenatal and neonatal risk stratification...

Le 07/05/2026

CONCLUSIONS: Our study supported tDCS use for improving overall behavioral symptoms of ASD in children and adolescents, mainly those pertinent to socio-communication, with fair treatment acceptability.

Le 06/05/2026

Children with autism spectrum disorder are known to exhibit both social and language difficulties. Speech prosody is known to be easily noticeable, which has been shown to have far-reaching influences in the academic and social life of autistic individuals. This study examined two training programs on the speech prosody of autistic children, who tend to avoid social speech signals. The first program is a lab perceptual training program without social interaction, while the second utilizes a...

Le 06/05/2026

CONCLUSIONS: A combination of tools such as the CSHQ, ESS-CHAD, PDSS, PSQ and SDSC may be useful for assessing sleep-wake disorders in children with ASD.

Le 06/05/2026

CONCLUSION: Integrating early neuroimaging and behavioral data suggests potential for prediction of ASD outcomes at 36 months in children with TSC. This multimodal machine learning framework highlights 24-month DTI and behavioral measures as key early biomarkers and demonstrates the effectiveness of regularized regression techniques for small-sample, heterogeneous clinical datasets.