Le 21/05/2026

Neurodevelopmental disorders (NDDs) are frequently associated with dysregulation of epigenetic mechanisms. Recent studies have implicated variants in components of the Male-Specific Lethal (MSL) complex, including MSL2, in NDD pathogenesis. However, the pathogenic mechanisms underlying MSL2-related neurodevelopmental disorders remain poorly defined. Here, we elucidate the role of MSL2 in neurodevelopment and NDDs through comprehensive analysis of conditional knockout mice and multi-omics...

Le 21/05/2026

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by core symptoms including impairments in social behavior and communication. The impaired excitatory and inhibitory signals have been implicated in the pathophysiology of social behavior deficits. Altered calretinin (CR)-containing GABAergic interneurons have been observed in ASD, but their roles and underlying mechanisms remain unveiled. Here, using valproic acid (VPA)-exposed mice for CR-Cre and R26::LS-tdTomato...

Le 21/05/2026

Autism spectrum disorder (ASD) is caused by an interaction of both environment and genetics. Recently, there has been an increased focus on how environmental toxins may alter a child's biological systems. Microplastics and nanoplastics are of great interest to researchers due to their ubiquitous nature and potential to interact with the human body. Through ingestion, inhalation and dermal contact, humans can consume both sizes of particles, which may enter the blood stream and under some...

Le 21/05/2026

CONCLUSIONS: Our findings demonstrate a strong positive correlation between the age-standardised prevalence and DALYs rate of ASD and sociodemographic index (SDI) across most countries. The health impact of ASD has been on an upward trajectory over the past three decades. ASD significantly contributes to health loss, particularly among preschool boys. The disease burden of ASD in China is likely to increase progressively in the future, highlighting the urgency of implementing targeted prevention...

Le 21/05/2026

AIMS: Neurophysiological impairments in basic sensory processes are a hallmark feature in schizophrenia (SZ) and are commonly reported in individuals at-risk of developing SZ. Autism spectrum disorder (ASD) is linked to a higher incidence of later psychotic disorders, including SZ. However, it remains unclear whether basic sensory risk markers for SZ are equally characteristic of ASD.

Le 21/05/2026

Individuals with autism spectrum disorder (ASD) report experiencing many difficulties associated with ASD and the pursuit of higher education. This study examines 34 years of data from a large private university in the U.S., comparing students with autism who registered with disability services (n = 177) to matched neurotypical peers on several academic record variables. Results indicate that students with ASD had more failing grades, were more likely to be put on academic discipline status and...

Le 21/05/2026

CONCLUSION: These findings define a metabolic-epigenetic placental phenotype in the BTBR mouse and support a model in which altered lipid droplet remodeling is associated with distinct chromatin states in key placental cell populations.

Le 21/05/2026

CONCLUSION: The MBSR program was effective in reducing depression, anxiety, and stress among parents of children with ASD. However, overall hopelessness did not change significantly, suggesting that this construct may be less responsive to short-term interventions.

Le 21/05/2026

No abstract

Le 21/05/2026

CONCLUSION: DST in individuals with autism might be understood as a modification in the structure of embodied perception and auditory attunement, beyond a mere sensory alteration. From a phenomenological perspective, DST reflects a particular relational configuration with the auditory world that shapes embodiment, affectivity, and intersubjectivity. These findings contribute to the emerging phenomenological psychopathology of autism by describing how auditory experience can participate in the...

Le 21/05/2026

Interpersonal synchrony (IS), a key indicator of social interactions, is traditionally assessed through video data and manual coding methods, a process that is time-consuming and subjective. This study presents an automated sensor-based framework for quantifying and visualizing IS using time series data collected from wearable sensors, demonstrated through a case study of interactions between autistic and neurotypical children in classroom settings. We evaluated time series similarity measures,...

Le 21/05/2026

ObjectiveNon-suicidal self-injury (NSSI) is frequently linked to dysfunctional family dynamics. While certain parental characteristics have been identified as risk factors, specific maternal social-cognitive traits remain underinvestigated. This study aimed to examine autistic traits and mentalization skills in biological mothers of adolescents engaging in NSSI.MethodsThe sample consisted of 100 female adolescents divided into three groups: Suicide Attempt and NSSI (n = 34), NSSI-only (n = 41),...

Le 21/05/2026

CONCLUSION: These findings suggest the importance of adaptive service delivery systems that maintain continuity of care during crises. Strengthening autism service infrastructure and developing resilient models are essential to safeguard autism support for future emergencies.

Le 21/05/2026

CONCLUSIONS: Findings indicate group-level changes in depression symptoms and synchronous evolution of anxiety and depression symptoms in autistic youth across childhood and adolescence. This indicates the importance of joint monitoring of anxiety and depression symptoms in this period, with changes being potentially informative for early detection and intervention. Considering how anxiety symptom presentation may evolve across development may be a helpful next step to identifying at-risk...

Le 21/05/2026

CONCLUSIONS: Despite limitations, findings suggest that the telehealth adaptation of FYF was an important resource during the COVID-19 pandemic for adolescents with autism and anxiety. Future research should incorporate participant feedback to improve the feasibility of virtual interventions.