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Le 31/07/2026

CONCLUSION: Mothers integrated emotion-focused (especially spiritual) and problem-focused strategies, influenced by Iranian cultural, religious, and collectivist contexts, underscoring needs for culturally tailored interventions, stigma reduction, and enhanced support services to bolster resilience.

Le 30/07/2026

Artificial intelligence (AI) has been increasingly integrated into autism interventions to support personalization and scalability; however, the strength of empirical evidence supporting these approaches remains unclear. In this systematic review, we synthesized and critically appraised experimental studies evaluating AI-based interventions for autistic individuals with a specific focus on intervention outcomes and methodological rigor. Following Preferred Reporting Items for Systematic Reviews...

Le 30/07/2026

Auditory processing is widely understood to occur differently in autism, though the patterns of brain activity underlying these differences are not well understood. The diversity of autism also means brain-wide networks may change in various ways to produce similar behavioral outputs. We used larval zebrafish to investigate auditory habituation in three genetic lines relevant to autism: fmr1, mecp2, and cntnap2 In free-swimming behavioral tests, we found each line had a unique profile of...

Le 30/07/2026

CONCLUSIONS: Our proof-of-concept study shows the immense potential of TAD for differential diagnostics: data collection only requires microphones and webcams while feature-extraction is automated, making this approach highly objective, scalable and user-friendly.

Le 30/07/2026

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and repetitive behaviors, with genetic studies implicating widespread synaptic dysfunction. However, the contribution of presynaptic vesicle trafficking mechanisms to ASD pathogenesis remains incompletely understood. Here, we identify synaptotagmin-like protein 4 (SYTL4), a RAB27A effector previously characterized in secretory cells, as a regulator of presynaptic function in the...

Le 30/07/2026

Executive functions (EFs) are higher order cognitive skills that enable individuals to regulate impulses, retain information, filter out distractions, and shift attention in response to changing demands. Various measures have been developed to assess these functions in toddlers across different contexts. However, convergence between these measures has not yet been established. Nor has it been verified whether these measures work in similar ways among children more-likely to experience EF...

Le 30/07/2026

CONCLUSION: This study adds to the conceptualisation of QoL for Autistic children and adolescents by eliciting directly the views of Autistic adolescents. The findings can inform the development of individual supports and increase understanding of Autistic perspectives in research and the community, which better enable Autistic adolescents to live a 'good life'. Further research should extend this work to include younger Autistic children and those with higher support needs.

Le 30/07/2026

CONCLUSIONS: These findings highlight that fathers' mental health experiences and help-seeking are shaped by identity-level processes that current services have not adequately addressed. Cultural stigma surrounding autism and masculine role expectations influence how fathers interpret and respond to psychological distress by encouraging functional self-monitoring and discouraging emotional disclosure, thereby delaying help-seeking and under-recognition of clinically relevant distress in fathers....

Le 30/07/2026

INTRODUCTION: Immersive virtual environments offer organized social contexts for the observation of communication behaviors under standardized and interactive conditions. This study adopts a VR-based observational approach to examine pragmatic social communication behaviors exhibited during structured social scenarios in autistic children, with a specific focus on social reciprocity and context-appropriate verbal communication.

Le 30/07/2026

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized not only by differences in social communication and restricted or repetitive behaviors, but also by variable profiles of motor function, sleep, cognition, sensory processing, and adaptive participation. Exercise and structured physical activity have emerged as promising non-pharmacological interventions in ASD, with growing evidence supporting benefits across multiple outcome domains, including executive...

Le 30/07/2026

Autistic individuals and those around them often navigate social and emotional situations in which behaviors, intentions, and affects are difficult to interpret. Supporting mentalizing processes within child-caregiver interactions may help address these challenges; however, a broader conceptual shift is needed, moving beyond a narrow deficit-based perspective toward understanding mentalization as a multidimensional, relational, and developmental process. By shifting the focus from individual...

Le 30/07/2026

Maternal diabetes, encompassing gestational diabetes mellitus and pre-existing type 1 and type 2 diabetes are associated with adverse perinatal outcomes. Emerging evidence suggests that maternal hyperglycemia and insulin resistance may be associated with long-term neurodevelopmental outcomes, particularly increasing the risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). This review synthesizes current epidemiological and mechanistic evidence linking...

Le 30/07/2026

Sexuality is a fundamental part of human development and should be addressed in its physical, emotional, and social dimensions. However, when it involves autistic children and adolescents, the topic remains marked by taboos, silence, and misinformation, especially within families. To understand the experiences of caregivers of autistic children and adolescents in Brazil and Spain regarding communication about sexuality, a qualitative narrative study was carried out based on Bronfenbrenner's...

Le 29/07/2026

In some children with autism, fever improves cognition. However, it remains unclear whether the thermal or immune components of fever are responsible for this improvement. Using the Scn2a^(+/-) autism mouse model, we demonstrate that fever-like temperatures, independent of direct immune activation, normalize cognitive function. In behavioral tests assessing learning of an escape route, Scn2a^(+/-) juvenile mice at normal body temperature fail to learn, whereas wild-type mice at normal body...

Le 29/07/2026

Synaptic dysfunction and resulting imbalance of excitatory vs. inhibitory transmission are fundamental aspects of autism spectrum disorders (ASD). Here we addressed the role of inhibitory synapse disturbances in ASD employing mice with a conditional ablation in GABAergic forebrain interneurons of the presynaptic active zone scaffolding protein Bassoon (Bsn), a key factor in synaptic development, activity and maintenance. The conditional Bsn gene knockout resulted in a reduction of synaptic...