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Modifié le 27/05/2024

Favorable responses to upadacitinib, a JAK1 inhibitor, in long COVID patients with predominant neuropsychiatric symptoms: case reports in 2 autistic patients and one typically developing patient

Le Tue, 19 Aug 2025 06:00:00 -0400

The long-term impact of coronavirus disease 2019 (COVID-19) has become evident over the past 3-4 years, with the recognition of post-COVID long-term sequelae, often referred to as long COVID. Neuropsychiatric symptoms are one of the hallmarks of long COVID. In severe cases, it can even present features of encephalopathy. Since some of the neuropsychiatric symptoms associated with long COVID overlap symptoms found in neuropsychiatric disorders, it has been difficult to sort out the effects of...

Elucidating the interplay between gut microbiota and autism spectrum disorder. New insights and therapeutic perspectives

Le Tue, 19 Aug 2025 06:00:00 -0400

Autism is a complex neurodevelopmental disorder characterized by a wide range of cognitive, behavioural and communication impairments. Children with autism have a distinctive and underdeveloped range and volume of gut bacteria (microbiome) which is often not related to their diet. Evidence gathered throughout years of research suggests that the pathway between gut bacteria and the central nervous system, referred to as the gut-brain axis (GBA), has a profound effect on the social behaviours of...

Developmental exposure to methyl ester sulfonate induces autism-like behavioral deficits in mice by dysregulation of the Notch/Hes signaling pathway disrupting neuronal differentiation

Le Tue, 19 Aug 2025 06:00:00 -0400

Developmental exposure to environmental pollutants is increasingly recognized as a significant risk factor for autism spectrum disorder (ASD), yet the specific mechanisms by which individual toxicants contribute to this neurodevelopmental disorder remain largely unknown. Methyl ester sulfonate (MES), a widely used anionic surfactant with widespread environmental detection, lacks comprehensive evaluation for developmental neurotoxicity. Here, we exposed pregnant mice to environmentally relevant...

Coexistence of autism spectrum disorder traits in adults diagnosed with attention-deficit/hyperactivity disorder: longitudinal outcomes

Le Tue, 19 Aug 2025 06:00:00 -0400

CONCLUSIONS: The study shows a high rate of co-existence of ASD in adults with ADHD. Comorbid ASD traits were associated with poorer overall clinical and functional outcomes, quality of life, social skills, and family functioning. Study limitations with particular reference to dropout rate are considered. Implications for improving services are discussed.

Perception of Biological Motion and Actions in Autism: a Systematic Review

Le Mon, 18 Aug 2025 06:00:00 -0400

Detecting and recognising the Biological Motion (BM) of other people provides essential information to understand others' actions and intentions, thus facilitating social interactions. Difficulties with social interaction are a hallmark of autism and may stem from altered perceptual recognition or interpretation of others' actions. This systematic review investigates whether BM perception in autistic individuals is influenced by the different categories of BM processing and the methodological...

Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism

Le Mon, 18 Aug 2025 06:00:00 -0400

Autism is a common neurodevelopmental disorder that despite its complex etiology, is marked by deficits in prediction that manifest in a variety of domains including social interactions, communication, and movement. The tendency of individuals with autism to focus on predictable schedules and interests that contain patterns and rules highlights the likely involvement of the cerebellum in this disorder. One candidate-autism gene is contactin-associated protein 2 (CNTNAP2), and variants in this...

Caregiving for children with autism in africa: A scoping review of socioeconomic impact with a call for intersectoral collaboration

Le Mon, 18 Aug 2025 06:00:00 -0400

Autism is a neurodevelopmental condition recognized as a significant global public health concern. However, there is limited understanding of the socioeconomic impact on caregivers in Africa. This scoping review synthesizes evidence from studies across African nations to examine the socioeconomic burdens faced by caregivers of children with autism. An extensive literature search was conducted across databases including PubMed, Scopus, Web of Science, and African Journals Online (AJOL) using...

Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics

Le Mon, 18 Aug 2025 06:00:00 -0400

Quality of life (QoL) is important for everyone and has been identified as a priority for autistic people. However, studies typically focus on caregiver-proxy-reported QoL and its related individual characteristics, even though self- and caregiver-proxy-reported QoL may differ in autistic children. In 74 autistic children (5.04-10.99 years old, intelligence quotient [IQ] 47-141), we sought to determine the level of agreement between self- and caregiver-proxy-reported QoL and determine if self-...

Sociodemographic and Clinical Characteristics of Children Who Lose the Autism Spectrum Disorder Diagnosis

Le Mon, 18 Aug 2025 06:00:00 -0400

Background: The objective of this research is to present the demographic and clinical features of children diagnosed with autism spectrum disorder (ASD) in the past, who have achieved an optimal level of improvement. One of the recurrent inquiries of the parents of children with an ASD diagnosis pertains to the prognosis of their offspring and the potential for improvement. This study aims to investigate children who lose the ASD diagnosis (LAD). Methods: This study retrospectively reviewed the...

Correction: A Descriptive Study on the Impacts of Hyperbaric Oxygen Therapy on Autistic Individuals Using Parent Testimonies

Le Mon, 18 Aug 2025 06:00:00 -0400

[This corrects the article DOI: 10.7759/cureus.55648.].

Correction: The Effects of Hyperbaric Oxygen Treatment on Verbal Scores in Children With Autism Spectrum Disorder: A Retrospective Trial

Le Mon, 18 Aug 2025 06:00:00 -0400

[This corrects the article DOI: 10.7759/cureus.51654.].

Functional upper-extremity movements in autism: A narrative literature review

Le Mon, 18 Aug 2025 06:00:00 -0400

CONCLUSIONS: Upper extremity movement differences in autism are likely the result of differences in motor planning and increased online monitoring of movement execution. Limitations and potential bias exist in the racial, ethnic, age, and gender diversity of available data, and in the variability of methods used to assess performance. However, the current body of literature suggests significant differences between autistic and non-autistic upper extremity movements. Slower, more variable upper...

The Association of Preterm Birth With Autism Spectrum Disorder

Le Mon, 18 Aug 2025 06:00:00 -0400

No abstract

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