Modifié le 27/05/2024
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Epigenetic Dysregulation of the Wnt/beta-Catenin Pathway via FTO-m6A in the mPFC Contributes to Autism-Like Behaviors
Le 24/06/2026
Post-transcriptional modifications of RNA, particularly m6A methylation, are emerging as critical epigenetic regulators of neurodevelopment and behavior. Although the RNA demethylase, fat mass and obesity-associated (FTO) protein has been implicated in autism spectrum disorder (ASD), the precise mRNA targets and downstream molecular pathways through which it governs behavior remain unclear. Here, we identify a significant upregulation of FTO in the medial prefrontal cortex (mPFC) of BTBR mice, a...
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A Color Preference Recognition System for Children with Autism Spectrum Disorder Based on Fully Flexible Triboelectric Sensors and Artificial Intelligence Technology
Le 24/06/2026
Appropriate color intervention can effectively regulate the autonomic arousal level of children with autism, improve their attention, and mitigate their anxiety. In consideration of the issues associated with traditional intervention methods, including cumbersome procedures and the inability to dynamically track the color-selection behavior of children with autism, this paper presents a fully flexible triboelectric sensor based on liquid metal. This sensor utilizes the current direct writing...
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Parent Support Group for Korean Immigrant Families of Individuals With Autism and Developmental Disabilities: Use of Academic-Community Partnership
Le 24/06/2026
CONCLUSIONS: This approach has resulted in a strong, ongoing academic-community partnership that has lasted for more than 2 decades and successfully engaged over 400 families. The lessons learned offer an example of how to reduce barriers to autism-related services by leveraging community strengths and fostering collaboration and by revisiting both the partnership and supports for families to more strongly address community priorities.
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Is Workplace Inclusion a Distinct Research Domain? A Comparative Bibliometric Study of Autism and Employment Literature
Le 24/06/2026
CONCLUSION: Multiple bibliometric indicators consistently differentiate outcome-oriented and inclusion-oriented corpora, indicating distinct but conceptually adjacent strands of scholarship. Inclusion-oriented research has grown at a rate substantially exceeding overall field expansion. Findings provide hypothesis-generating evidence consistent with disciplinary diversification and highlight the need for integrative frameworks linking vocational rehabilitation and organizational inclusion...
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Effects of Physical Exercise on Motor Skills in Children With Autism Spectrum Disorder: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Le 24/06/2026
CONCLUSION: Physical exercise significantly improves motor skills in children with ASD. Meta-regression indicates that frequency is a positive moderator for balance gains, but prolonged duration shows diminishing returns due to adaptation plateaus. Age and session length did not affect the protocol, so it remained flexible.
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The Links Between Parents' Self-Stigma, Parental Burnout, Parental Competence, and Socio-Emotional Adjustment Among Parents of Children With Autism Spectrum Disorder
Le 24/06/2026
CONCLUSION: These results provide important insights for mental health professionals and intervention programs, highlighting the need to address self-stigma and burnout to foster parental competence and socio-emotional well-being in families of children with ASD.
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Efficacy and Safety of Cannabinoid-Based Products in Children and Adolescents with Autism Spectrum Disorder, Fragile X Syndrome and Rett Syndrome: A Systematic Review
Le 24/06/2026
CONCLUSION: CBPs may offer potential benefits for selected behavioral symptoms and comorbid epilepsy in pediatric NDDs, but current evidence is insufficient to support routine clinical use. High-quality randomized controlled trials with standardized outcome measures and long-term follow-up are needed to clarify efficacy, safety, and syndrome-specific effects.
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GABA(A) receptor dysfunction in autism spectrum disorder: molecular mechanisms and therapeutic opportunities
Le 24/06/2026
Autism spectrum disorder (ASD) comprises diverse neurodevelopmental trajectories in which altered circuit dynamics converge on a disturbance of excitation-inhibition balance. Genetic, postmortem, neuroimaging, and model-system evidence implicates γ-aminobutyric acid type A (GABA(A)) receptors as a major molecular node within this imbalance. ASD has been associated with changes in GABA(A) receptor subunit expression and assembly, notably within 15q11-q13 clusters, impaired receptor trafficking...
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Individualized Behavioral Management Techniques to Facilitate and Maintain Dental Treatment in a Child With Autism Spectrum Disorder: A Case Report
Le 24/06/2026
Autism spectrum disorder (ASD) presents significant challenges in dental practice due to impairments in communication, sensory processing, and behavioral regulation. This case report describes the management of a five-year-old male child with ASD who exhibited anxiety, hypersensitivity to auditory stimuli, and limited cooperation during dental visits. An individualized, non-pharmacological behavioral approach was implemented, including desensitization, the tell-show-do technique, non-verbal...
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Gut microbiome dynamics in autism: a prospective nested case-control study demonstrates microbial-clinical associations following rehabilitation interventions
Le 24/06/2026
CONCLUSION: This study demonstrates that rehabilitation intervention synchronously ameliorates clinical symptoms and modulates the gut-metabolic profile in ASD. The identified associations between specific metabolites (ornithine and tyrosine) and clinical outcomes suggest a metabolic mechanism underlying the gut-brain axis, highlighting the potential of these metabolites as biomarkers for therapeutic monitoring. Further large-scale studies are needed to validate these findings.
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Mental health disorders and suicide risk among autistic children, adolescents and adults: a population-based study using linked administrative data
Le 24/06/2026
BACKGROUND: Autistic people face elevated mental health risks, yet few population-based studies have quantified these risks across developmental stages. We examined the prevalence and relative risk of physician-diagnosed mental health disorders and suicide attempts among autistic individuals in the province of Manitoba, Canada, using linked administrative health data.
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Prdm15 Deficiency Results in Impaired Hippocampal Neurogenesis and Autism-Like Behaviors
Le 23/06/2026
Autism spectrum disorder (ASD) is a complex, heterogeneous neurodevelopmental disorder, with epidemiological studies consistently reporting a rising prevalence worldwide. Our previous human genetic sequencing analysis identified PRDM15 (PRDI-BF1 (Positive regulatory domain I-binding factor 1) and RIZ1 (Retinoblastoma protein-interacting zinc finger 1) homologous domain-containing protein 15), a transcriptional regulator and a member of the PRDM family, as a novel candidate risk gene for ASD....
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Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Turkiye
Le 23/06/2026
CONCLUSIONS: Severe mealtime behavioural dysregulation in ASD intrinsically compromises diet quality and elevates parental psychosocial burden. Clinical management requires a multidisciplinary, family-centred approach integrating behavioural feeding support with caregiver stress management.
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Reply to the Letter to the Editor on: impact of screen use on behavior and sleep in patients with autism spectrum disorder
Le 23/06/2026
No abstract
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Letter regarding "Impact of screen use on behavior and sleep in patients with autism spectrum disorder"
Le 23/06/2026
No abstract
