Veille Pubmed

Le 27/08/2026

CONCLUSION: Although caregivers in both groups reported moderate quality of life, those caring for children with autism spectrum disorder experienced substantially greater caregiver burden. These findings support the need for targeted strategies to reduce caregiver stress and improve well-being in families of children with autism spectrum disorder.Brazilian Registry of Clinical Trials: RBR-4cvz58n and U1111-1299-9942.

Le 27/08/2026

Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease mechanisms and therapeutic opportunities. Using affinity purification-mass spectrometry, we systematically mapped PPIs for 100 high-confidence ASD genes, uncovering more than 1800 interactions. By assessing the impact of pathogenic missense mutations, leveraging AlphaFold, and validating key...

Le 27/08/2026

Phenomenological approaches have gained increasing traction in autism mental health studies, yet what phenomenology specifically contributes, beyond a general orientation toward lived experience, has received little scrutiny. This paper takes up two questions: why phenomenology, rather than other methods of perspective-taking, is needed in autism mental health research and clinical practice, and what it is concretely for. The stance adopted throughout is that autism is, in agreement with the...

Le 27/08/2026

CONCLUSION: The findings contribute to the existing literature by emphasising how sensory sensitivities and gender identity distress intensify each other and how the transition from child to adolescence, and the body, is perceived. Results indicate tailored clinical implications for adolescents experiencing ASD and GI. Clinicians should consider multidisciplinary collaboration, individualised and flexible interventions that address both sensory regulation and gender-related support to improve...

Le 27/08/2026

CONCLUSIONS: Results may signal challenges with using the existing K-CAT^(®) to assess autistic youth. K-CAT^(®) adaptations are likely necessary to improve accessibility, linguistic clarity, and diagnostic specificity and will be important to promote scalable, equitable MH screening for autistic youth.

Le 27/08/2026

Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Using population-representative UK primary care records, we defined three autistic groups-autistic adults with intellectual disability (ID), autistic adults without ID and all autistic adults-and four non-autistic groups....

Le 27/08/2026

Self-injurious behaviors (SIBs) affect up to 50% of autistic individuals and significantly impact quality of life and everyday functioning. Cross-sectional studies link the presence of SIB to lower IQ, altered sensory responsivity, and poor emotion regulation, yet their effect on changes in SIB severity from early childhood to school age in autism remains poorly understood. We examined SIBs in 325 autistic children assessed at age 2-5 years (T1) and 161 autistic children at 4-9 years (T3). This...

Le 27/08/2026

Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autistic brain, it has been overlooked in research investigating sensory challenges in autism. Previous evidence has linked sensory over-responsivity in autism to altered neural habituation in sensory and limbic regions, but...

Le 27/08/2026

INTRODUCTION: Autism spectrum disorders (ASD) have a global prevalence of 1%, with a male-to- female diagnosis ratio of roughly 4:1. Several models have been developed to predict ASD using genetic information. However, the influence of biological sex on prediction outcomes remains underexplored.

Le 27/08/2026

CONCLUSION: Aquatic exercise may improve overall ASD-related symptoms or behaviors in children with ASD. Evidence for motor function and other specific outcomes remains limited, heterogeneous, and exploratory.

Le 27/08/2026

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by deficits in social interaction and the presence of repetitive, stereotyped behaviors, often accompanied by gastrointestinal symptoms. The prevalence of ASD is on the rise, and the lack of specific pharmacological treatments places a significant burden on families and society. However, the discovery of the microbiota-gut-brain axis (MGBA) offers new opportunities for research into ASD. The gut microbiota, a...

Le 27/08/2026

CONCLUSION: Our study identifies recurrent de novo missense variants in DDX23 as the genetic cause of a neurodevelopmental syndrome. Functional assays in Drosophila confirm the disease-causing potential of these variants and support a gain-of-function mechanism for the p.(Arg528Cys) and p.(Arg528His) alleles.

Le 27/08/2026

No abstract

Le 27/08/2026

CONCLUSIONS: Overall, this analysis provides support for a potentially important role of oxytocin in language development in autistic children and suggests that it may have therapeutic utility for individuals with language problems.

Le 27/08/2026

CONCLUSION: These findings provide insights into the economic challenges experienced by families of children with ASD in Kazakhstan and suggest the importance of continued development of government support.