Le 12/06/2026

CONCLUSIONS: These findings suggest that the combination of prenatal VPA exposure and postnatal hypoxia, representing pre- and perinatal insults, induces ASD-like conditions in rat pups that closely resemble the clinical behaviour features and redox imbalance of human ASD. Thus, this combined model could serve as a potential animal model for ASD and could be used for screening pharmacological agents aimed at treating and managing ASD.

Le 12/06/2026

[This corrects the article DOI: 10.3389/fncel.2026.1717636.].

Le 12/06/2026

CONCLUSIONS: The similarity of leftward attention mechanisms across groups, which includes intact recruitment of anticipatory alpha modulation, argues against a global disruption of basic visuo-spatial attentional function in autistic individuals with low support needs. However, group differences emerged specifically during rightward attention, where ASD participants showed a more uniform pattern of oscillatory modulation, warranting further investigation. Collectively, these findings provide...

Le 12/06/2026

Social behavior deficits are a common symptom of neuropsychiatric disorders, including autism spectrum disorder (ASD), but there are limited pharmacological treatments for these symptoms. Understanding how neurons encode social information will give insight into identifying novel pharmacological targets to address this unmet need. SHANK3 encodes a postsynaptic scaffold protein and is a common risk gene for several neuropsychiatric disorders characterized by social deficits, including ASD. Our...

Le 12/06/2026

Autism spectrum disorder (ASD) is increasingly conceptualized as a condition rooted in altered prenatal neurodevelopment, yet in vivo evidence from fetal brain imaging remains limited. Using retrospective fetal MRI and surface-based morphometry, we investigated cortical development in 15 fetuses later diagnosed with ASD (77%; mean gestational age [GA] = 26.7 weeks) without major structural brain abnormalities and compared them with 60 typically developing controls (57% male; mean GA = 28.4...

Le 12/06/2026

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition shaped by contributions from hundreds of genes, many of which remain poorly characterized. This largely uncharacterized genomic landscape may therefore hold critical insight into how diverse molecular disruptions converge on shared social phenotypes. Here, we investigated KIAA0232 (mouse orthologue D5Ertd579e ), an uncharacterized locus lacking known functional domains, using a global null knockout mouse model. While...

Le 12/06/2026

The Lancet Commission on the Future of Care and Clinical Research in Autism proposed the construct of "profound autism" as a recognizable subtype of autism. Supporters argue that this classification is necessary to ensure that autistic persons with severe impairment receive appropriate research attention and policy support, whereas critics contend that the construct lacks scientific validity and may reflect social or political considerations more than biological distinction. To inform this...

Le 12/06/2026

CONCLUSIONS: Autistic youth with strong verbal ability may experience diagnostic delays. SDOH interacts with VIQ in a complex fashion, with lower SDOH generally exacerbating the tendency for VIQ to be associated with later diagnosis across a large clinical sample. However, among autistic youth without complicating medical factors or intellectual disability, this relationship is dependent upon sex.

Le 12/06/2026

Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with substantial genetic heterogeneity. While coding variants have been extensively studied, non-coding regulatory variants-which constitute approximately 99% of the human genome-remain largely underexplored. Their functional impact, particularly at the single-cell level and in organoid models, requires further characterization to better understand how these variants contribute to ASD pathogenesis. Methods We...

Le 12/06/2026

CONCLUSIONS: Interventions for aggression in school-aged autistic children should consider aggression towards others, SIB, and social skills as separate targets, as changes in one domain did not appear to be related to changes in other domains.

Le 12/06/2026

Autism is a neurodevelopmental condition with challenges in establishing and sustaining social relationships and communication. Apigenin (AP) is a natural flavonoid with numerous valuable effects on brain disorders. The current study emerged to study the cerebellar histopathological changes in valproic acid (VPA)-induced autism in male albino rat pups and assess the possible neuroprotective role of AP in minimizing these alterations. Forty male albino rat pups were categorized randomly into four...

Le 12/06/2026

In today's society, autism spectrum disorder (ASD) is a common neurological disorder that affects a person's behavior and communication. Hence, an early ASD prediction is essential for improving the lifecycle of ASD patients. Recently, many works have been deployed for diagnosing ASD using the electroencephalogram (EEG) and magnetic resonance imaging (MRI). But they are inefficient owing to the irrelevant noises and misclassification outcomes. Hence, a well-ordered logistic regression with...

Le 12/06/2026

This paper aimed to unravel the effects of Yizhi Kaiqiao formula combined with repetitive transcranial magnetic stimulation (rTMS) on neurocognitive function and social outcomes in preschool children with autism spectrum disorder (ASD). In this randomized controlled trial, 178 preschool children with ASD recruited between January 2022 and February 2024 were randomly assigned to a combined group (Yizhi Kaiqiao formula + rTMS) or an rTMS-only group (n = 89 each). Both groups received a 3-month...

Le 12/06/2026

CONCLUSIONS: Although limited by a small sample size and lack of a control group, these findings provide preliminary evidence supporting the feasibility of implementing a metagenomics-guided personalized synbiotic framework in ASD and generate hypotheses for future investigation. This work presents a preliminary conceptual framework for integrating microbial composition and inferred functional profiling into individualized intervention design and highlights the potential value of...

Le 12/06/2026

Background/Objectives: Genetic and environmental factors during early development contribute to autism pathogenesis. Maternal autoantibodies recognizing specific fetal brain proteins can predict autism risk in a subset of cases. These antibodies cross the placenta and bind to their target antigens, which play critical roles in neurodevelopment, thereby increasing autism risk in this mechanistically defined subtype, Maternal Autoantibody-Related Autism (MARA). A multi-ELISA assay that detects...